Modeling of progesterone-induced intracellular calcium signaling in human spermatozoa

作者：Li Long Fei; Xiang Cheng; Zhu Ya Bing; Qin Kai Rong^*

来源：Journal of Theoretical Biology, 2014, 351: 58-66.

DOI：10.1016/j.jtbi.2014.02.026

• Human spermatozoa
• Calcium signaling
• Progesterone
• Mathematical modeling

Calcium ion is a secondary messenger of mammalian spermatozoa. The dynamic change of its concentration plays a vital role in the process of sperm motility, capacitation, acrosome and fertilization. Progesterone released by the cumulus cells, as a potent stimulator of fertilization, can activate the calcium channels on the plasma membrane, which in turn triggers the dynamic change of intracellular calcium concentration. In this paper, a mathematical model of calcium dynamic response in mammalian spermatozoa induced by progesterone is proposed and numerical simulation of the dynamic model is conducted. The results show that the dynamic response of calcium concentration predicted by the model is in accordance with experimental evidence. The proposed dynamic model can be used to explain the phenomena observed in the experiments and predict new phenomena to be revealed by experimental investigations, which will provide the basis to quantitatively investigate the fluid mechanics and biochemistry for the sperm motility induced by progesterone.

• 出版日期2014-6-21
• 单位大连理工大学