Antioxidant and alpha-amylase inhibitory activities of extract and isolates from Zygogynum pancheri subsp. arrhantum

作者：Keskes Henda; Litaudon Marc; Cherif Atef; Belhadj Sahla; Hamdi Besma; El Feki Abdelfattah; Dumontet Vincent; Ben Salah Abdelhamid; Damak Mohamed; Allouche Noureddine^*

来源：Journal of Asian Natural Products Research, 2014, 16(12): 1132-1138.

DOI：10.1080/10286020.2014.938646

• Zygogynum pancheri
• alpha-amylase
• drimane sesquiterpenoids
• tetralone
• antioxidant

One new sesquiterpenoid (5R(*),8R(*),9R(*),10R(*))-cinnamolide (8), and seven known compounds, 5-hydroxy-7-methoxyflavonone (1), 8-hydroxy-3-(4 '-hydroxyphenyl)-6,7-(2 '',2 ''-dimethylchromene)-tetralone (2), 8-hydroxy-3-(3 ',4 '-dihydroxyphenyl)-6,7-(2 '',2 ''-dimethylchromene)-tetralone (3), 1 beta-E-O-p-methoxycinnamoyl-bemadienolide (4), 1 beta-O-(E-cinnamoyl)-6 alpha-hydroxy-9-epi-polygodial (5), 1 beta-O-(E-cinnamoyl)-6 alpha-hydroxypolygodial (6), and 1 beta-O-E-cinnamoylpolygodial (7) were isolated from the ethyl acetate extract of barks of Zygogynum pancheri subsp. arrhantum (Winteraceae). The structures of these molecules were assigned predominantly based on spectral data. The structure of compound 8 was confirmed by X-ray crystallographic analysis. Compounds 2 and 3 exhibited significant antioxidant activity, whereas compounds 1 and 4-7 showed significant alpha-amylase inhibitory activity.

• 出版日期2014-12-2