科研之友
微信
新浪微博
Facebook
分享链接
摘要
A novel and efficient phosphine-catalyzed intramolecular cyclization of alpha-nitroethylaltenic esters is reported. This process appears to be practical for the stereoselective syntheses of (Z)-furan-2(3H)-one oxime derivatives in excellent, yields. Mechanistically, the reaction involves a phosphine-catalyzed Michael addition,of an alkylideneazinate and rearrangement of the cyclic nitronate to the alpha-nitrosodihydrofuran.
- 出版日期2016-6-17
- 单位中国药科大学
