Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals

作者：Tuomainen Marjo; Lindstrom Jaana; Lehtonen Marko; Auriola Seppo; Pihlajamaki Jussi; Peltonen Markku; Tuomilehto Jaakko; Uusitupa Matti; de Mello Vanessa D; Hanhineva Kati

来源：Nutrition & Diabetes, 2018, 8(1): 35.

DOI：10.1038/s41387-018-0046-9

<jats:title>Abstract</jats:title><jats:p>We recently reported using non-targeted metabolic profiling that serum indolepropionic acid (IPA), a microbial metabolite of tryptophan, was associated with a lower likelihood of developing type 2 diabetes (T2D). In the present study, we established a targeted quantitative method using liquid chromatography with mass spectrometric detection (HPLC-QQQ-MS/MS) and measured the serum concentrations of IPA in all the participants from the Finnish Diabetes Prevention Study (DPS), who had fasting serum samples available from the 1-year study follow-up (<jats:italic>n</jats:italic> = 209 lifestyle intervention and <jats:italic>n</jats:italic> = 206 control group). Higher IPA at 1-year study was inversely associated with the incidence of T2D (OR [CI]: 0.86 [0.73–0.99], <jats:italic>P</jats:italic> = 0.04) and tended to be directly associated with insulin secretion (<jats:italic>β</jats:italic> = 0.10, <jats:italic>P</jats:italic> = 0.06) during the mean 7-year follow-up. Moreover, IPA correlated positively with dietary fiber intake (g/day: <jats:italic>r</jats:italic> = 0.24, <jats:italic>P</jats:italic> = 1 × 10<jats:sup>−6</jats:sup>) and negatively with hsCRP concentrations at both sampling (<jats:italic>r</jats:italic> = − 0.22, <jats:italic>P</jats:italic> = 0.0001) and study follow-up (<jats:italic>β</jats:italic> = − 0.19, <jats:italic>P</jats:italic> = 0.001). Thus, we suggest that the putative effect of IPA on lowering T2D risk might be mediated by the interplay between dietary fiber intake and inflammation or by direct effect of IPA on β-cell function.</jats:p>

• 出版日期2018-5-25