Antidepressant effects of Radix et Caulis Acanthopanacis Santicosi extracts on rat models with depression in terms of immobile behavior

作者：Gaire Bhaktaprasad; Lim Dongwook^*

来源：Journal of Traditional Chinese Medicine, 2014, 34(3): 317-323.

DOI：10.1016/s0254-6272(14)60096-0

• Acanthopanax senticosus
• Antidepressive agents
• Stress
• Behavior

OBJECTIVE: To investigate the antidepressant effects of the Radix et Caulis Acanthopanacis Santicosiextracts in response to the tail suspension test (TST) and forced swim test (FST) in rats.
METHODS: Male Wistar rats (9-week-old) were orally administered the Radix et Caulis Acanthopanacis Santicosi extracts (30, 100 and 300 mg/kg) daily for 14 consecutive days. Serum corticosterone level was measured by using commercially available kit. The c-fos immunoreactivity was analyzed using immunohistochemistry methods.
RESULTS: The effect of Radix et caulis Acanthopanacis Santicosi extracts on the immobility time was significantly decreased at high-dose (300 mg/kg) treated group in the TST and FST (47.7% and 69.6%, P<0.05), and decreased the hypothalamic-pituitary-adrenal (HPA) axis response to the stress, as indicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippocampal and hypothalamic paraventricular nucleus region.
CONCLUSION: Radix et Caulis Acanthopanacis Santicosi extracts have beneficial effects on depression behaviors and restore both altered c-fos expression and HPA activity. Thus, Radix et Caulis Acanthopanacis Santicosi extracts may be a novel agent for the treatment of stress-related disorders.

• 出版日期2014-6-15