Nickel(II)-Catalyzed Asymmetric Michael Addition of Oxindoles with Modified N,N,O-Tridentate Chiral Phenanthroline Ligands

作者：Naganawa Yuki; Abe Hiroki; Nishiyama Hisao

来源：Synlett, 2016, 27(13): 1973-1978.

DOI：10.1055/s-0035-1561630

• asymmetric synthesis
• nickel
• oxindole
• Michael addition
• phenanthroline

Nickel(II)-catalyzed enantioselective Michael addition of N-Boc-oxindole derivatives with methyl vinyl ketone was demonstrated to give the corresponding adducts having chiral all-carbon quaternary centers with up to 87% ee in the presence of axially chiral N,N,O-tridentate phenanthroline ligand.

• 出版日期2016-8