New renal drug development to face chronic renal disease

作者：Moll Solange; Meier Matthias; Formentini Ivan; Pomposiello Silvia; Prunotto Marco^*

来源：Expert Opinion on Drug Discovery, 2014, 9(12): 1471-1485.

DOI：10.1517/17460441.2014.956075

• chronic kidney disease
• diabetic kidney disease
• drug discovery
• fibrosis
• inflammation
• renal diseases

Introduction: For the first time in 2012, chronic kidney diseases were added to WHO disease list because of their impact on morbidity/mortality and their substantial impact on the cost to the health care system. Although representing a clear unmet medical need and a huge business case for the pharmaceutical industry, its clinical treatment still mainly relies on drugs invented in the 1980s used for controlling blood pressure.
Areas covered: In this review, the authors aim to elucidate why renal drug development is feasible today. The article provides a particular focus on the treatments that target the pathways involved in inflammation, fibrosis and the core mechanisms driving the vicious cycle responsible for disease progression and organ function loss.
Expert opinion: Currently, it is plausible to develop effective therapeutics for renal diseases with a plethora of approaches available for their development at a preclinical and clinical level. Furthermore, the relevance of biomarkers and the use of surrogate rare disease indications as proof of mechanism for faster and/or smaller clinical development are now possible; and these developments could revolutionize the way we treat renal disease in the future.

• 出版日期2014-12