Antibody-based depletion of Foxp3+T cells potentiates antitumor immune memory stimulated by mTOR inhibition

作者：Kim Hyung L^*

来源：OncoImmunology, 2014, 3(6): e29081.

DOI：10.4161/onci.29081

• CD4
• regulatory T cells
• mTOR
• memory T cell
• tumor immunology

Inhibition of mTOR signaling enhances antitumor memory T lymphocytes while increasing the frequency of immunosuppressive regulatory T cells (Tregs). We report a strategy to further improve the quality and function of CD8(+) memory T cells using CD4-depleting monoclonal antibody therapy. Removal of Tregs was the mechanism underlying immunological memory formation following CD4 depletion.

• 出版日期2014-6