Neurotensin: Role in psychiatric and neurological diseases

作者：Caceda Ricardo^*; Kinkead Becky; Nemeroff Charles B

来源：Peptides, 2006, 27(10): 2385-2404.

DOI：10.1016/j.peptides.2006.04.024

• neurotensin
• dopamine
• schizophrenia
• antipsychotic drugs
• drugs of abuse
• Parkinson's disease

Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction.

• 出版日期2006-10