科研之友
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摘要
Inspired by the strong adhesive proteins secreted by mussels for attachment onto a wide range of substrates in wet condition, some reports indicated that polydopamine (PDA) possesses the similar structure and strong adhesion to those of adhesive proteins. PDA film can be formed on the surface of substrate in alkaline solution expeditiously, which results in the improvement of the hydrophily and the chemical versatility of substrate due to the hydrophilic hydroxyl and amino groups of PDA. The PDA layer can be used as an intermediate to anchor functional molecules on the surface through chemical bonds (by Michael addition or Schiff base reaction) or other physical bonds (hydrogen bond or van der Wools' force). PDA surface modification strategy is extremely useful because the process is simple and solvent-free. Moreover, due to the improvement of cell adhesion and biocompatibility, PDA has been widely used in surface modification of biomaterials. In this review, adhesive mechanism and application of PDA in surface modification of biomaterials have been summarized. In addition, the problems existed and the promising prospects of the application of PDA in biomaterials are pointed out. This review also provides useful information for the potential application of PDA in biomaterials and tissue engineering.
- 出版日期2015-3
- 单位西南交通大学
