Association of the G-174C variant in the Interleukin-6 promoter region with bone loss and fracture risk in older women

作者：Moffett SP^*; Zmuda JM; Cauley JA; Stone KL; Nevitt MC; Ensrud KE; Hillier TA; Hochberg MC; Joslyn G; Morin P; Cummings SR

来源：Journal of Bone and Mineral Research, 2004, 19(10): 1612-1618.

DOI：10.1359/JBMR.040707

• genetics
• polymorphism
• BMD
• interleukin 6
• fracture

We analyzed the association between the IL-6 G-174C polymorphism and osteoporosis phenotypes in 3376 older women. Women with the C/C genotype had a significantly slower rate of decline in hip BMD and a 33% lower risk of wrist fracture than women with the G/G genotype. Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility.

• 出版日期2004-10