Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction: The Towers Task

作者：Lourens, Spencer; Zhang, Ying; Long, Jeffrey D.; Paulsen, Jane S.^*

来源：Statistical Methods in Medical Research, 2017, 26(2): 865-879.

DOI：10.1177/0962280214560187

• Cognitive neuroscience
• Huntington disease
• mixed-effect model
• censored data
• semicontinuous data
• Towers Task

Executive dysfunction is a deficiency in skills of planning and problem solving that characterizes many neuropsychiatric disorders. The Towers Task is a commonly used measure of planning and problem solving for assessing executive function. Towers Task data are usually zero-inflated and right-censored, and ignoring these features can result in biased inference for the disease characterization of executive dysfunction. In this manuscript, a mixed-effects model for longitudinal censored semicontinuous data is developed for analyzing longitudinal Towers Task data from the PREDICT-HD study. The model is contrasted with current practice, and implications for general use are discussed.

• 出版日期2017-4
• 单位上海交通大学