摘要

An efficient and environmentally benign protocol for the synthesis of 3-(2'-benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones has been developed. The synthesis of these pharmacologically important compounds can be achieved by the three component condensation of isatoic/5-chloroisatoic anhydride, aldehyde, and 2-aminobenzothiazole in water: ethanol (1: 1, v/v) without the aid of any catalyst.
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  • 出版日期2011