科研之友
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摘要
Cholic acid (1) was transformed into methyl cholic acid (2) by esterification with methanol. Then, 2 was oxidized with pyridinium chlorochromate (PCC) to form methyl dehydrocholic acid (3). Selective reduction of 3 by NaBH4 in the presence of CoCl2 gave methyl 7 alpha-hydroxy-3,12-dioxocholan-24-oic acid (4). The structure of 4 was elucidated by IR, NMR and MS techniques. The cytotoxicity of 4 against some tumor cells was investigated, showing that 4 has antiproliferative activity toward sk-Hep-1 (human liver carcinoma cell line) and H-292 (human lung carcinoma cell line).
- 出版日期2009-6
- 单位南宁师范大学
