A pair of sulfonated diarylheptanoid epimers from Kaempferia galanga

作者：Wang Fang-Lin; Luo Jian-Guang; Wang Xiao-Bing; Kong Ling-Yi^*

来源：Chinese Journal of Natural Medicines, 2013, 11(2): 171-176.

DOI：10.3724/SP.J.1009.2013.00171

• Kaempferia galanga
• Zingiberaceae
• Sulfonated diarylheptanoids
• Electronic circular dichroism (ECD)
• Induced circular dichroism (ICD)

AIM: To discover new bioactive, constituents from Kaempferia galanga L. (Zingiberaceae). METHODS: The extract of K. galanga was divided into the chloroform and water-soluble portions. The latter fraction was successively subjected to column chromatography over a D101 macroporous adsorption resin, MCI, Sephadex LH-20, and preparative HPLC to obtain two compounds. RESULTS: Two novel sulfonated diarylheptanoid epimers, namely kaempsulfonic acids A (1) and B (2), were isolated from the rhizomes of K galanga. Their structures were established by analysis of spectroscopic data. The absolute configurations of 1 and 2 were determined by the comparison of experimental electronic circular dichroism (ECD) spectroscopy and the computational calculation method, combined with Mo-2(OAc)(4)induced circular dichroism (ICD). CONCLUSION: The isolates 1 and 2 are new compounds and their absolute configurations were determined for the first time.

• 出版日期2013-3
• 单位中国药科大学