A small interfering ABCE(1)-targeting RNA inhibits the proliferation and invasiveness of small cell lung cancer

作者：Huang, Bo; Gao, Ying; Tian, Dali^*; Zheng, Maogen

来源：International Journal of Molecular Medicine, 2010, 25(5): 687-693.

DOI：10.3892/ijmm_00000392

• ABCE1
• small cell lung cancer
• siRNA
• NCI-H446

Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm. To study the pathogenesis of SCLC, we investigated roles of ABCE1, a member of the ATP-binding cassette (ABC) superfamily, in the development of small cell lung cancer. RNA interference was used to knock down ABCE1 expression in human small cell lung cancer cell lines (NCI-H446). Then we examined the effects of ABCE1 knockdown in cancer cells, including proliferation, invasiveness, apoptosis, and gene expression. We found that ABCE1 could be efficiently knocked down by siRNA, and the ABCE1 silence inhibited the proliferation, invasiveness of small cell lung cancer cell lines NCI-H446. In conclusion, our results suggest that ABCE(1) play an important role in the pathogenesis of human small cell lung cancer cell. ABCE(1) may be used as a potential target of gene therapy for small cell lung cancer in future.

• 出版日期2010-5
• 单位中国医科大学