Are macrocyclic lactones useful drugs for the treatment of Parascaris equorum infections in foals?

作者：Veronesi Fabrizia; Fioretti Daniela Piergili; Genchi Claudio^*

来源：Veterinary Parasitology, 2010, 172(1-2): 164-167.

DOI：10.1016/j.vetpar.2010.04.019

• Parascaris equorum
• Moxidectin
• Ivermectin
• Efficacy

A study was carried out to assess the field efficacy of moxidectin (MOX) against Parascaris equorum in foals A total of 70 foals from 2 Italian thoroughbred (Farms 1 and 2) stud farms and one trotter stud farm (Farm 3) aged 3-5 months and with faecal egg counts (FEc) f >= 300 eggs per gram (EPG) were included in the study On each farm foals were divided Into 2 groups (of 10 8 and 10 foals respectively) and treated with either moxidectin (MOX 400 mcg/kg b w) or ivermectin (IVM 200 mcg/kg b w) on day 0 and examined for faecal count reduction (FECR) on day 14 Five 4 and 5 foals respectively were kept as untreated controls An individually based estimation of efficacy was assessed by a bootstrap simulation to evaluate the percent reduction of FECRs Two thousand bootstrap resamples were constructed from individual FECRs and the parasite population was considered susceptible for FECs >= 90% and 95% lower confidence limit (CL) >90% suspected resistant for FECRs >= 90% and 95% LCL <90% and resistant when FECR <90% and 95% [CL <90% On day 14 foals with FECRs categorized as resistant or suspected resistant were treated with pyrantel pamoate (PYR 13 2 mg/kg b w) and examined for FECR on days 28 and 35 On day 14 MOX and IVM treatments were ineffective in all foals from both thoroughbred farms while MOX ad IVM were effective (FECRs >90%) in 7 and 5 trotter foals respectively and remained >90% until day 35 P

• 出版日期2010-8-27