Amberlyst-15A (R) in PEG: A novel catalytic system for the facile and efficient one-pot synthesis of benzothiazolo-[2,3-b]-quinazolinone derivatives

作者：Mazaahir Kidwai^*; Ritika Chauhan; Divya Bhatnagar

来源：Science China Chemistry, 2012, 55(10): 2154-2160.

DOI：10.1007/s11426-012-4665-z

• Amberlyst-15 (R)
• benzothiazolo-[2,3-b]-quinazolinones
• multi-component reaction
• reusability
• PEG (polyethylene glycol)
• green chemistry

A simple and convenient approach for the synthesis of tetraheterocyclic benzothiazolo-[2,3-b]-quinazolin-1-ones has been developed utilizing the MCR methodology, which involves the condensation of 2-aminobenzothiazole, cyclic beta-diketones and various aldehydes using Amberlyst-15A (R) in PEG 400 as an environmentally benign and reusable catalyst system. Environmental benignity, recyclability, cost-effectiveness, easy workup and excellent yields are the major attributes of this one-pot procedure.

• 出版日期2012-10