A facile synthesis and IR-LD spectral elucidation of N-acetyl amino acid derivatives

作者：Chapkanov A G^*; Dzimbova T A; Ivanova B B

来源：Bulgarian Chemical Communications, 2012, 44(3): 228-232.

• alpha-amino acids
• N-acetyl-derivatives
• IR-LD spectral analysis

The synthesis of N-acetyl derivatives of a-amino acids (L-Gly, L-Val, L-Phe, L-Ile, L-Pro and L-Cys) using a simple and efficient method for preparation was carried out. The N-acetyl derivatives were obtained using acetic anhydride in basic conditions at room temperature. The methyl amides of N-acetyl amino acid were synthesized by mixed anhydride procedure using a Piv-Cl as a reagent. The conventional and IR-LD spectral analysis were applied for elucidation and characterization of typical IR-bands of the starting and intermediate compounds. Spectral investigation includes IR-characteristic bands assignment and elucidation of amino acids as zwitterions structures - L-Valine (L-Val), L-Proline (L-Pro) L-Cystein (L-Cys) and their intermediates by linear-dichroic infrared (IR-LD) spectroscopy of oriented solid sample as a nematic liquid crystal suspension. The experimental IR-characteristic bands obtained, were accompanied with spectral elucidation and structural prediction of the investigated compounds.

• 出版日期2012
• 单位西南大学