Base-By-Base Ratcheting of Single Stranded DNA through a Solid-State Nanopore

作者：Luan Binquan^*; Peng Hongbo; Polonsky Stas; Rossnagel Steve; Stolovitzky Gustavo; Martyna Glenn

来源：Physical Review Letters, 2010, 104(23): 238103.

DOI：10.1103/PhysRevLett.104.238103

We investigate the base-by-base translocation dynamics of single-stranded DNA (ssDNA) confined in a solid-state nanopore dressed with an electrostatic trap, using all-atom molecular dynamics (MD) simulation. We observe on the simulation time scale of tens of nanoseconds that ssDNA can be driven through the nanopore in a ratchetlike fashion, with a step size equal to the spacing between neighboring phosphate groups in the ssDNA backbone. A 1D-Langevin-like model is derived from atomistic dynamics which can quantitatively describe simulation results and can be used to study dynamics on longer time scales. The controlled ratcheting motion of DNA could potentially enhance the signal-to-noise ratio for nanoelectronic DNA sensing technologies.

• 出版日期2010-6-10