ANALGESIC, ANTIPYRETIC AND ANTI-INFLAMMATORY ACTIVITIES OF GREWIA ASIATICA FRUIT EXTRACTS IN ALBINO MICE

作者：Akhtar Bushra; Ashraf Muhammad; Javeed Aqeel; Sharif Ali; Akhtar Muhammad Furqan; Saleem Ammara; Hamid Irfan; Alvi Sadia; Murtaza Ghulam^*

来源：Acta Poloniae Pharmaceutica, 2016, 73(4): 983-989.

• Grewia asiatica fruit
• carrageenan induced paw edema
• analgesic
• antipyretic

The present study was aimed to assess biological (analgesic, antipyretic and anti-inflammatory) activities of methanolic and aqueous fruit extracts of Gawk, asintica. The study was performed on albino mice. Analgesic effect of the extracts was determined by acetic acid induced writhing. Antipyretic potential of the tested fruit extracts was assessed by brewer's yeast induced pyrexia. Carrageenan induced paw edema method was used to evaluate the anti-inflammatory activity. Both the extracts showed biological effects in a dose dependent fashion at doses 125 mg/kg, 250 mg/kg and 500 mg/kg orally. Analysis of variance (ANOVA) was used for data analysis and the values having p-value smaller than 0.05 were considered significant. Both the extracts had significant analgesic, antipyretic and anti-inflammatory activities.

• 出版日期2016-8