Nanotechnology Applications in Stem Cell Science for Regenerative Engineering

作者：Vernekar Varadraj N; James Roshan; Smith Kevin J; Laurencin Cato T^*

来源：Journal of Nanoscience and Nanotechnology, 2016, 16(9): 8953-8965.

DOI：10.1166/jnn.2016.12738

• Nano
• Micro
• Stem
• Cell
• Tissue
• Regenerative
• Engineering

Stem cell science in concert with nanotechnology has the potential to revolutionize tissue regeneration and healing outcomes. Nanotechnology allows the creation of biomaterials with unique and defined properties that mimic the extracellular matrix (ECM) in the tissue and present temporal and spatial cues to develop 3-D multi-scale complex tissue systems. Control of the ECM environment is key to controlling the fate of the stem cells that reside in it. Whereas, tunable nanotopographical cues presented by a biomimicking scaffold can promote dynamic control over cellular function, nanotechnology-based processes and materials can also enable cellular manipulation via the delivery of trophic factors, genetic information, signaling molecules, and modulation of the immune response. Integration of multiple processes, including nanofabrication, nanomaterial-biomolecular interactions, and understanding the subsequent cellular responses to these nanofabricated materials is vital to directing the proliferation and differentiation of stem cells and regenerating the desired tissues without scar formation. Nanotechnology based labeling and tracking of stem cells is allowing us to understand these cellular responses better and monitor the progress of tissue development in a non-invasive manner. Concurrent progress in stem cell science and developmental biology along with enabling technologies from nanotechnology and tissue engineering are bringing the development of complex tissue systems such as limbs one step closer to reality through what we define as a new paradigm: regenerative engineering. This review focuses on nanotechnology applications in stem cell science for regenerative engineering.

• 出版日期2016-9