New metabolites produced by Fusarium solani T-13 isolated from a dead branch

作者：Shiono Yoshihito^*; Ariefta Nanang Rudianto; Anwar Chairil; Matsjeh Sabirin; Sappapan Ruengrit; Murayama Tetsuya; Koseki Takuya; Kawamura Tetsuaki; Uesugi Shota; Kimura Ken ichi

来源：Phytochemistry Letters, 2016, 17: 232-237.

DOI：10.1016/j.phytol.2016.08.003

• Fusarium solani
• Lasiodiplodin
• Endophytes
• Ca2+ signaling inhibition activity

Three novel benzenediol lactone derivatives, 7-hydroxy-14-de-O-methyl-lasiodiplodin (2), ethyl-3,5dihydroxy- 7-(6,8-dihydroxynonyl) benzoate (4), and 7-ethylbenzoate-7-heptanoic acid (5), together with known compounds, 14-de-O-methyl-lasiodiplodin (1) and ethyl-3,5-dihydroxy-7-(8-hydroxynonyl) benzoate (3), were isolated from the culture of Fusarium solani T-13, a fungus from a dead branch. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compounds 1, 3 and 4 showed doughnut like phenotypes of growth restoring activity against the mutant yeast (zds1 Delta erg3 Delta pdr1/3 Delta) at the concentration of 0.16, 0.63 and 1.25 mg/spot, respectively.

• 出版日期2016-9