An Electrochemistry Study of Cryoelectrolysis in Frozen Physiological Saline

作者：Manuel Thomas J^*; Munnangi Pujita; Rubinsky Boris

来源：IEEE Transactions on Biomedical Engineering, 2017, 64(7): 1654-1659.

DOI：10.1109/TBME.2016.2627402

• Cryoelectrolysis
• cryoelectrolytic ablation
• cryogenics
• cryosurgery
• electrolysis
• electrolytic ablation
• frozen tissue
• tissue ablation

Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the processes of electrolysis and solid/liquid phase transformation (freezing). This study investigated this new technique by measuring the pH front propagation and the changes in resistance in a tissue simulant made of physiological saline gel with a pH dye as a function of the sample temperature in the high subzero range above the eutectic. Results demonstrated that effective electrolysis can occur in a high subzero freezing milieu and that the propagation of the pH front is only weakly dependent on temperature. These observations are consistent with a mechanism involving ionic movement through the concentrated saline solution channels between ice crystals at subfreezing temperatures above the eutectic. Moreover, results suggest that Joule heating in these microchannels may cause local microscopic melting, the observed weak dependence of pH front propagation on temperature, and the large changes in resistance with time. A final insight provided by the results is that the pH front propagation from the anode is more rapid than from the cathode, a feature indicative of the electro-osmotic flow from the cathode to the anode. The findings in this paper may be critical for designing future cryoelectrolytic ablation surgery protocols.

• 出版日期2017-7