Anticancer activities of some arylcarbamoylalkyltriphenylphosphonium chlorides

作者：Lou Zhaowen^*; Zhou Li; Xiao Chunfen; Ye Yong; Zeng Fanbo; Huang Kaixun

来源：Medicinal Chemistry Research, 2007, 16(7-9): 380-391.

DOI：10.1007/s00044-007-9050-7

• phosphonium
• synthesis
• characterization
• anticancer activity

A series of novel arylcarbamoylalkyltriphenylphosphonium chlorides were synthesized. The newly synthesized compounds, [R-(p-C6H4)-NH-CO-R1P circle plus (C6H4)(3)] C1(theta), R = H (2), CH3 (4), NO2 (6), R-1 = -CH2-(b), CH3CH<(a), -CH2CH2- (c), -CH2CH2CH2 (d), the analogs of an anticancer drug, were characterized by infrared (IR), H-1 nuclear magnetic resonance (NMR), C-13-NMR, (PNMR)-P-31, mass spectrometry ( MS), thermogravimetry ( TG), and conductivity measurements. The anticancer activities of the obtained compounds were measured by MTT. The preliminary results indicated that some compounds showed potent anticancer activities against HCT-8, Bel-7402, A549, and S180.

• 出版日期2007-12
• 单位华中科技大学; 湖北大学