Association between IgG N-glycans and Nonalcoholic Fatty Liver Disease in Han Chinese

作者：Zhao Zhong Yao; Liu Di; Cao Wei Jie; Sun Ming; Song Man Shu; Wang Wei; Wang You Xin^*

来源：Biomedical and Environmental Sciences, 2018, 31(6): 454-458.

DOI：10.3967/bes2018.059

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Nonalcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. Immunoglobulin G (IgG) N-glycans are associated with risk factors for NAFLD, such as obesity and diabetes. A cross-sectional study involving 500 Han Chinese adults recruited from a community in Beijing was carried out to explore the association between IgG N-glycans and NAFLD. IgG N-glycosylation was significantly associated with NAFLD, with the disease showing a negative correlation with galactosylation (GP14, GP14(n), and G2(n)), positive correlation with fucosylation (FBG2(n)/G2(n)), and positive correlation with bisecting N-acetylglucosamine (GlcNAc) [FBG2(n)/FG2(n) and FBG2(n)/(FG2(n)+FBG2(n))], after controlling age, gender, and prevalence of obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia. In other words, the present study showed a possible association between NAFLD and the loss of galactose and elevations of fucose and bisecting GlcNAc. Aberrant IgG glycosylation might therefore be a potential biomarker for the primary or secondary prevention of NAFLD.

• 出版日期2018-6
• 单位首都医科大学