Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran

作者：Hashemi Mohammad; Zakeri Zahra^*; Taheri Hamed; Bahari Gholamreza; Taheri Mohsen

来源：Iranian Journal of Allergy, Asthma and Immunology, 2015, 14(3): 255-260.

• PADI4
• Polymorphism
• Rheumatoid arthritis

There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA). The aim of the present study was to investigate the impact of PADI4 rs1748033 polymorphism and susceptibility to RA in a sample of the Iranian population.
This case-control study was done on 150 patients with RA and 150 healthy subjects. PADI4 rs1748033 genotyping was done using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) assay.
The PADI4 rs1748033 variant increased the risk of RA in codominant (OR = 1.67, 95% CI = 1.03-2.71, p = 0.048, CT vs CC; OR = 2.73, 95% CI = 1.25-5.97, p = 0.013, TT vs CC) and dominant (OR = 1.84, 95% CI = 1.15-2.92, p = 0.014, CT+TT vs CC) tested inheritance models. In addition, the PADI4 rs1748033 T allele increased the risk of RA (OR = 1.63, 95% CI = 1.16-2.29, p = 0.006) in comparison with C allele.
In conclusion, our finding indicated that PADI4 rs1748033 gene polymorphism increased the risk of RA in a sample of the Iranian population.

• 出版日期2015-6