Secondary Metabolites and Bioactivity of the Endophytic Fungus Phomopsis theicola from Taiwanese endemic plant

作者：Hsiao Yi; Chang Hsun Shuo; Liu Ta Wei; Hsieh Sung Yuan; Yuan Gwo Fang; Cheng Ming Jen^*; Chen Ih Sheng^*

来源：Records of Natural Products, 2016, 10(2): 189-194.

• Phomopsis theicola
• endophytic fungus
• Litsea hypophaea
• phomocytochalasin

A new cytochalasan named as phomocytochalasin (1), together with five previously identified compounds, cytochalasin H, cytochalasin N, RKS-1778, dankasterone B, cyclo(L-Ile-L-Leu), were isolated from the solid fermentate of Phomopsis theicola BCRC 09F0213, an endophytic fungus isolated from the leaves of an endemic Formosan plant Litsea hypophaea Hayata. The structure of the new compound was established by spectroscopic methods, including UV, IR, HR-ESIMS, and extensive 1D- and 2D-NMR techniques. Among the isolates, cytochalasin N showed NO inhibitory activity with IC50 values of 77.8 M. Cytochalasin H showed the progesterone receptor (PR) antagonism with the IC50 value of 1.42 mu M.

• 出版日期2016