Mitochondrial dysfunction in DDR-related cancer predisposition syndromes

作者：Lyakhovich Alex; Graifer Dmitry; Stefanovie Barbora; Krejci Lumir

来源：Biochimica et Biophysica Acta-Reviews on Cancer, 2016, 1865(2): 184-189.

DOI：10.1016/j.bbcan.2016.02.006

• Mitochondrial dysfunction
• DNA damage and repair
• Cancer predisposition syndromes
• Oxidative stress
• ROS
• Autophagy
• Mitophagy

Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysMDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy.

• 出版日期2016-4