Ammonium acetate mediated synthesis of 5-substituted 1H-tetrazoles

作者：Patil Dipak R; Deshmukh Mukesh B; Dalal Dipak S^*

来源：Journal of the Iranian Chemical Society, 2012, 9(5): 799-803.

DOI：10.1007/s13738-012-0080-9

• 5-Substituted 1H-tetrazole
• Nitrile
• NaN3
• Ammonium acetate
• [3+2] Cycloaddition

Synthesis of 5-substituted 1H-tetrazoles was achieved by [3+2] cycloaddition of nitriles and sodium azide in the presence of ammonium acetate. The reaction proceeds in situ formation of ammonium azide. Present protocol has advantage of good to excellent yields, short reaction times and simple isolation of products than reported methods.

• 出版日期2012-10