Design, Synthesis and Bioactivities of Phenylamino-Pyrimidine Derivatives as Novel Protein Tyrosine Kinase Inhibitors

作者：Hong, Xinfu; Kuang, Xianzhao; Ding, Guohua; Liu, Yilin; Liu, Jinlin; Zhao, Yanjin; Li, Shuxin^*

来源：Letters in Drug Design and Discovery, 2011, 8(7): 596-601.

DOI：10.2174/157018011796235202

• Protein tyrosine kinase
• Phenylamino-pyrimidine
• Synthesis
• Bioactivity

A series of novel phenylamino-pyrimidine derivatives were designed and synthesized as antitumor agent based on the lead compound of Imatinib by application of the principle of bioisosterism, hybridization and structural optimization. The bioactivities of the new target compounds were tested against human KU812 cells in vitro, some target compounds show promising activities and can be considered for further development.

• 出版日期2011-8
• 单位中国人民解放军军事医学科学院; 江西中医药大学