Facile synthesis of gamma-alkylidenebutenolides from Morita-Baylis-Hillman adducts

作者：Park Bo Ram; Kim Ko Hoon; Lim Jin Woo; Kim Jae Nyoung^*

来源：Tetrahedron Letters, 2012, 53(1): 36-40.

DOI：10.1016/j.tetlet.2011.11.001

• gamma-Alkylidenebutenolides
• Morita-Baylis-Hillman adducts
• Isomerization
• Indium

An expedient synthetic procedure of gamma-alkylidenebutenolides was developed via a sequential indium-mediated Barbier-type reaction of Morita-Baylis-Hillman bromide with aldehyde, lactonization, and double-bond isomerization. Various gamma-alkylidenebutenolides including bovolide and its derivatives were synthesized in good overall yields.

• 出版日期2012-1-4