Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers

作者：Lane Kevin J^*; Levy Jonathan I; Scammell Madeleine K; Peters Junenette L; Patton Allison P; Reisner Ellin; Lowe Lydia; Zamore Wig; Durant John L; Brugge Doug

来源：Environment International, 2016, 92-93: 173-182.

DOI：10.1016/j.envint.2016.03.013

• Ultrafine particles
• Time-activity
• Systemic inflammation
• Particle number concentration
• Cardiovascular risk

Background: Long-term exposure to fine particulate matter has been linked to cardiovascular disease and systemic inflammatory responses; however, evidence is limited regarding the effects of long-term exposure to ultrafine particulate matter (UFP, <100 nm). We used a cross-sectional study design to examine the association of long-term exposure to near-highway UFP with measures of systemic inflammation and coagulation.
Methods: We analyzed blood samples from 408 individuals aged 40-91 years living in three near-highway and three urban background areas in and near Boston, Massachusetts. We conducted mobile monitoring of particle number concentration (PNC) in each area, and used the data to develop and validate highly resolved spatiotemporal (hourly, 20 m) PNC regression models. These models were linked with participant time-activity data to determine indiyidual time-activity adjusted (TAA) annual average PNC exposures. Multivariable regression modeling and stratification were used to assess the association between TAA-PNC and single peripheral blood measures of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor-necrosis factor alpha receptor II (TNFRII) and fibrinogen.
Results: After adjusting for age, sex, education, body mass index, smoking and race/ethnicity, an interquartile-range (10,000 partides/cm(3)) increase in TAA-PNC had a positive non-significant association with a 14:0% (95% CI: -4.6%, 362%) positive difference in hsCRP, an 8.9% (95% CI: -0.4%, 10.9%) positive difference in IL-6,,and a 5.1% (95% CI: -0.4%, 10.9%) positive difference in TNFRII. Stratification by race/ethnicity revealed that TM-PNC had larger effect estimates for all three inflammatory markers and was significantly associated with hsCRP and TNFRII in white non Hispanic, but not East Asian participants. Fibrinogen had a negative non-significant association with TAA-PNC
Conclusions: Our findings suggest an association between annual average near-highway TM-PNC and subclinical inflammatory markers of CVD risk.

• 出版日期2016-8