科研之友
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摘要
Invasion and metastasis are major factors in the poor prognosis of pancreatic cancer, which remains one of the most aggressive and lethal diseases worldwide. alpha-mangostin, a major xanthone compound identified in the pericarp of mangosteen (Garcinia mangostana, Linn; GML), possesses unique biological activities, including antioxidant, antitumor and antiinflammatory effects. Whether alpha-mangostin is able to inhibit the invasive ability of pancreatic cancer cells has not been elucidated. In the present study, alpha-mangostin was shown to inhibit the invasive ability of the pancreatic cancer cell lines MIAPaCa-2 and BxPC-3. The results showed that alpha-mangostin inhibited the growth of the pancreatic cancer cells in a dose- and timedependent manner. At concentrations of <5 mu M, alpha-mangostin had no significant effects on cytotoxicity, but significantly inhibited the invasion and migration of pancreatic cancer cells and the expression of matrix metalloproteinase (MMP)-2 and MMP-9, while increasing the expression of E-cadherin. The present data also showed that alpha-mangostin exerted an inhibitory effect on the phosphorylation of extracellular-signal-regulated kinase (ERK). Furthermore, the reduction of ERK phosphorylation by small interfering RNA (siRNA) potentiated the effect of alpha-mangostin. Taken together, the data suggest that alpha-mangostin inhibited the invasion and metastasis of pancreatic cancer cells by reducing MMP-2 and MMP-9 expression, increasing E-cadherin expression and suppressing the ERK signaling pathway. The present study suggests that alpha-mangostin may be a promising agent against pancreatic cancer.
- 出版日期2013-6
- 单位延安大学
