An efficient strategy for functionalized spirolactones and dispirodihydrofuranyl oxindoles using amines and activated alkynes

作者：Kiruthika Selvarangam E; Amritha Rangarajan; Perumal Paramasivan T^*

来源：Tetrahedron Letters, 2012, 53(26): 3268-3273.

DOI：10.1016/j.tetlet.2012.04.047

• Huisgen dipolar additions
• Spirolactones
• Bisoxindoles
• Dihydrofurans
• Primary amines
• Activated alkynes

A facile strategy for the synthesis of functionalized spirolactones from isatin, primary amines, and activated alkynes through Huisgen dipolar additions are discussed. A novel route for the formation of dispirodihydrofuranyl oxindoles from activated cyclic electrophiles, amines, and DMAD has also been developed. This method offers several advantages like high yield, readily available starting materials, and involves less hazardous chemical techniques.

• 出版日期2012-6-27