Lack of Correlation Between Metallic Elements Analyzed in Hair by ICP-MS and Autism

作者:De Palma Giuseppe*; Catalani Simona; Franco Anna; Brighenti Maurizio; Apostoli Pietro
来源:Journal of Autism and Developmental Disorders, 2012, 42(3): 342-353.
DOI:10.1007/s10803-011-1245-6

摘要

A cross-sectional case-control study was carried out to evaluate the concentrations of metallic elements in the hair of 44 children with diagnosis of autism and 61 age-balanced controls. Unadjusted comparisons showed higher concentrations of molybdenum, lithium and selenium in autistic children. Logistic regression analysis confirmed the role of risk factor for male gender and showed a slight association with molybdenum concentrations. Unconventional chelation and vitamin-mineral supplementation were ineffective on elemental hair concentrations. A meta-analysis including the present and previous similar studies excluded any association of autism with hair concentrations of mercury, cadmium, selenium, lithium and copper. A slight association was found for lead only, but it was very weak, as strictly dependent on the worst data from one study.

  • 出版日期2012-3