科研之友
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摘要
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPAR. and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPAR. on metabolism and cellular differentiation, abundant evidence suggests that PPAR. is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro-and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPAR. in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.
- 出版日期2008
