Association of serum chemerin concentrations with the presence of atrial fibrillation

作者：Zhang, Guowei; Xiao, Mochao; Zhang, Lili^*; Zhao, Yue; Yang, Qinghui

来源：Annals of Clinical Biochemistry, 2017, 54(3): 342-347.

DOI：10.1177/0004563216664367

• Chemerin
• atrial fibrillation
• left atrial diameter

Objective: Chemerin, a newly discovered adipokine, is correlated with hypertension, diabetes and coronary heart disease. The aim of this study is to investigate the association of serum chemerin concentrations with the presence of atrial fibrillation.
Methods: Serum chemerin concentrations were determined in 256 patients with atrial fibrillation and 146 healthy subjects. Atrial fibrillation patients were then divided into paroxysmal, persistent and permanent atrial fibrillation.
Results: Serum chemerin concentrations were significantly higher in atrial fibrillation patients compared with healthy controls. In subgroup studies, patients with permanent atrial fibrillation had higher serum chemerin concentrations than those with persistent and paroxysmal atrial fibrillation. Furthermore, significant higher serum chemerin concentrations were observed in persistent atrial fibrillation patients compared with paroxysmal atrial fibrillation subjects. Serum chemerin concentrations were associated with the presence of atrial fibrillation after logistic regression analysis. Pearson correlation analysis revealed a positive relation of serum chemerin concentrations with body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, low-density lipoprotein cholesterol, blood urea nitrogen, creatinine, C-reactive protein and left atrial diameter.
Conclusion: Serum chemerin concentrations are associated with the presence of atrial fibrillation and atrial remodelling.

• 出版日期2017-5
• 单位哈尔滨医科大学