Association between baseline IL-6 and 1-year recovery in lumbar radicular pain

作者：Schistad E I^*; Espeland A; Pedersen L M; Sandvik L; Gjerstad J; Roe C

来源：European Journal of Pain, 2014, 18(10): 1394-1401.

DOI：10.1002/j.1532-2149.2014.502.x

BackgroundIn the present study, the influence of cytokines on 1-year recovery in lumbar radicular pain was examined.
MethodsIn total, 110 patients with symptomatic lumbar disc herniation were followed for 1 year. Uni- and multivariate linear regression was used to assess the influence of interleukin (IL)-6, IL-8, disc degeneration and endplate changes (Modic changes) on the changes in the Oswestry Disability Index (ODI change; primary outcome) and visual analogue scale (VAS) for low back pain (LBP) and leg pain (secondary outcomes).
ResultsLess favourable ODI outcome correlated with higher serum IL-6 levels (B=-3.41, 95% CI -5.52 to -1.30, p=0.002), non-surgical treatment (B=-7.03, 95% CI 1.21 to 12.84, p=0.018), higher baseline back pain intensity (B=-2.28, 95% CI -3.21 to -1.35, p<0.001) and low educational level (B=-5.57, 95% CI 0.66 to 10.47, p=0.027). High VAS for LBP and leg pain at 1 year was associated with high levels of serum IL-6, higher back pain intensity and longer duration of lumbar radicular pain at baseline.
ConclusionsHigh serum IL-6 levels, but not disc degeneration or Modic changes, were associated with less favourable recovery in patients with lumbar radicular pain. Intense initial back pain, non-surgical treatment, lower educational level and longer duration of radicular pain before treatment also correlated with a slower recovery the first year after disc herniation.

• 出版日期2014-11