House Dust Mite Induced Lung Inflammation Does Not Alter Circulating Vitamin D Levels

作者：Chen Ling^*; Perks Kara L; Stick Stephen M; Kicic Anthony; Larcombe Alexander N; Zosky Graeme

来源：PLos One, 2014, 9(11): e112589.

DOI：10.1371/journal.pone.0112589

Low circulating levels of 25-hydroxyvitaminD [25(OH)D] are associated with chronic lungDiseases such as asthma. However, it is unclear whether vitaminD is involved inDisease pathogenesis or is modified by the inflammation associated with theDisease process. We hypothesized that allergic inflammationDecreases the level of circulating 25(OH)D and tested this using a mice model of houseDust mite (HDM) induced allergic airway inflammation. Cellular influx was measured in bronchoalvelar lavage (BAL) fluid, and allergic sensitization and 25(OH)D levels were measured in serum. Exposure to HDM caused a robust inflammatory response in the lung that was enhanced by prior influenza infection. These responses were not associated with any change in circulating levels of 25(OH)D. TheseData suggest that alterations in circulating 25(OH)D levels induced by Th-2Driven inflammation are unlikely to explain the cross-sectional epidemiological association between vitaminDDeficiency and asthma.

• 出版日期2014-11-12
• 单位河北医科大学