ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

作者：Larson Nicholas B; Bell Elizabeth J; Decker Paul A; Pike Mindy; Wassel Christina L; Tsai Michael Y; Pankow James S; Tang Weihong; Hanson Naomi Q; Alexander Kristine; Zakai Neil A; Cushman Mary; Bielinski Suzette J

来源：Atherosclerosis, 2016, 251: 422-429.

DOI：10.1016/j.atherosclerosis.2016.05.049

• Cellular adhesion
• Von willebrand factor
• Multi-ethnic
• ABO

Background and aims: ABO blood type is associated with cardiovascular disease, although the underlying mechanisms are presumed to be complex. While the relationship between non-O blood types and von Willebrand Factor (vWF) is well-established, associations with cellular adhesion molecules (CAMs) across diverse populations are understudied.
Methods: We genetically inferred ABO alleles for N = 6202 participants from the Multi-Ethnic Study of Atherosclerosis. Linear regression was used to evaluate associations between major ABO allele dosages and log-transformed measurements of vWF (N = 924), soluble E-selectin (sE-selectin, N = 925), soluble P-selectin (sP-selectin, N = 2392), and soluble ICAM-1 (sICAM-1, N = 2236) by race/ethnicity.
Results: For the selectins, the A1 allele was associated with significantly lower levels for all races/ethnicities, with each additional allele resulting in a 28e39% decrease in sE-selectin and 10-18% decrease in sP-selectin relative to Type O subjects. However, the A2 allele demonstrated effect heterogeneity across race/ethnicity for sE-selectin, with lower levels for non-Hispanic whites (p = 0.0011) but higher levels for Hispanics (p = 0.0021). We also identified elevated sP-selectin levels for B-allele carriers solely in Hispanic participants (p = 1.0E-04). ABO-by-race/ethnicity interactions were significant for both selectins (p < 0.0125). More modest associations were observed between A1 allele dosage and levels of sICAM-1, with ABO alleles explaining 0.8-1.1% of the total phenotypic variation within race/ethnicity. ABO associations with vWF activity were consistent across race/ethnicity, with B allele carriers corresponding to the highest vWF activity levels.
Conclusions: ABO blood type demonstrates complex associations with endothelial markers that are largely generalizable across diverse populations.

• 出版日期2016-8