Association Between Pulse Wave Velocity and a Marker of Renal Tubular Damage (N-Acetyl-beta-D-Glucosaminidase) in Patients Without Diabetes

作者：Ouchi Motoshi^*; Oba Kenzo; Saigusa Taro; Watanabe Kentaro; Ohara Makoto; Matsumura Noriaki; Suzuki Tatsuya; Anzai Naohiko; Tsuruoka Shuichi; Yasutake Masahiro

来源：Journal of Clinical Hypertension, 2015, 17(4): 290-297.

DOI：10.1111/jch.12492

The authors assessed the association between the ratio of urinary activity of N-acetyl--D-glucosaminidase (NAG) to creatinine and the brachial-ankle pulse wave velocity (baPWV) in patients without overt diabetes mellitus (DM). This was a cross-sectional study of 233 patients who had an estimated glomerular filtration rate (eGFR) 30mL/min/1.73m(2) and no history of kidney disease. Patients were divided into two groups: high NAG group (>5.8U/gcreatinine) and low NAG group (5.8U/gcreatinine). Mean baPWVs of the high NAG group were significantly higher than those of the low NAG group in both the eGFR 30 and <60tertiles and the eGFR 60 and <90tertiles. The baPWV was positively correlated with NAG in all patients (r=0.341, P<.001). Stepwise multivariate regression analysis showed that the baPWV was significantly related with NAG, age, and systolic blood pressure. Elevated NAG is related to elevated arterial stiffness in patients without DM.

• 出版日期2015-4