MtDNA VARIATION WITHIN LOCAL HUMAN POPULATIONS IN BOSNIA AND HERZEGOVINA

作者：Kapur Pojskic Lejla; Pojskic Naris^*; Radosavljevic Gabrijela; Marjanovic Damir; Hadziselimovic Rifat

来源：Genetika-Belgrade, 2014, 46(1): 209-218.

DOI：10.2298/GENSR1401209K

• human mtDNA diversity
• HVS1 motif
• haplogroups
• population structure

Being a crossroad of many ancient and recent historical migrations, Bosnia and Herzegovina (B&H) represents unique spot of multicultural and social diversity. The main aim of this study was to assess genetic structure of three local populations of mountain area from central part of B&H using mtDNA HVS-1 as an informative marker for population genetics studies.
A 444 bp HVS-1 segment of control region of mtDNA extracted from buccal swabs was PCR amplified and sequenced. Haplotype and nucleotide diversity, average number of nucleotide differences, AMOVA and pairwise F-ST based on mtDNA haplotype and haplogroup frequencies were calculated. NJ tree was constructed based on pairwise F-ST results. Tajima's D was calculated to evaluate population demographic status.

• 出版日期2014