A three-factor preoperative scoring model predicts risk of recurrence after liver resection or transplantation in hepatocellular carcinoma patients with preserved liver function

作者：Li, Yang; Ruan, Dan-Yun; Yi, Hui-Min; Wang, Guo-Ying; Yang, Yang; Jiang, Nan^*

来源：Hepatobiliary and Pancreatic Diseases International, 2015, 14(5): 477-484.

DOI：10.1016/S1499-3872(15)60412-X

• hepatocellular carcinoma
• liver resection
• liver transplantation
• total tumor volume
• plasma fibrinogen

BACKGROUND: No staging systems of hepatocellular carcinoma (HCC) are tailored for assessing recurrence risk. We sought to establish a recurrence risk scoring system to predict recurrence of HCC patients receiving surgical curative treatment (liver resection or transplantation). @@@ METHODS: We retrospectively studied 286 HCC patients with preserved liver function receiving liver resection (n=184) or transplantation (n=102). Independent risk factors were identified to construct the recurrence risk scoring model. The recurrence free survival and discriminatory ability of the model were analyzed. @@@ RESULTS: Total tumor volume, HBsAg status, plasma fibrinogen level were included as independent prognostic factors for recurrence-free survival and used for constructing a 3-factor recurrence risk scoring model. The scoring model was as follows: 0.758xHBsAg status (negative: 0; positive: 1)+0.387x plasma fibrinogen level (<= 3.24 g/L: 0; >3.24 g/L: 1)+0.633x total tumor volume (<= 107.5 cm(3): 0; >107.5 cm(3): 1). The cutoff value was set to 1.02, and we defined the patients with the score <= 1.02 as a low risk group and those with the score >1.02 as a high risk group. The 3-year recurrence-free survival rate was significantly higher in the low risk group compared with that in the high risk group (67.9% vs 41.3%, P<0.001). In the subgroup analysis, liver transplantation patients had a better 3-year recurrence-free survival rate than the liver resection patients in the low risk group (80.0% vs 64.0%, P<0.01). Additionally for patients underwent liver transplantation, we compared the recurrence risk model with the Milan criteria in the prediction of recurrence, and the 3-year recurrence survival rates were similar (80.0% vs 79.3%, P=0.906). @@@ CONCLUSION: Our recurrence risk scoring model is effective in categorizing recurrence risks and in predicting recurrence-free survival of HCC before potential surgical curative treatment.

• 出版日期2015-10
• 单位中山大学