Daidzein inhibits carbohydrate digestive enzymes in vitro and alleviates postprandial hyperglycemia in diabetic mice

作者：Park Mi Hwa; Ju Jae Won; Park Min Jung; Han Ji Sook^*

来源：European Journal of Pharmacology, 2013, 712(1-3): 48-52.

DOI：10.1016/j.ejphar.2013.04.047

• Daidzein
• alpha-glucosidase
• Postprandial hyperglycemia
• Diabetic mice

This study was designed to investigate whether daidzein inhibits alpha-glucosidase and alpha-amylase activities and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Daidzein showed prominent inhibitory effects against alpha-glucosidase and alpha-amylase. The IC50 values of daidzein against alpha-glucosidase and alpha-amylase were 0.048 and 0.301 mmol, respectively, which showed that daidzein was more effective than acarbose. The increase in postprandial blood glucose levels was more significantly suppressed in the daidzein-administered group than in the water group of both streptozotocin-induced diabetic and normal mice. Moreover, the area under the curve was significantly lowered following daidzein administration (2043 versus 2475 mmol min l) in the streptozotocin-induced diabetic mice. These results indicated that daidzein may be a potent alpha-glucosidase inhibitor and suppress the postprandial hyperglycemia caused by starch.

• 出版日期2013-7-15