Age-and sex-related effects on ankle-brachial index in a screened cohort of Japanese: the Okinawa Peripheral Arterial Disease Study (OPADS)

作者：Ishida Akio^*; Miyagi Megumi; Kinjo Kozen; Ohya Yusuke

来源：European Journal of Preventive Cardiology, 2014, 21(6): 712-718.

DOI：10.1177/2047487312462822

• Ageing
• ankle-brachial index
• arteriosclerosis
• sex differences

Aims: Age-related change of ankle-brachial index (ABI) within the general population, especially %26lt;40 years, has not been determined in large population studies. We evaluated the value of the ABI by age-and sex-related differences in a screened cohort. %26lt;br%26gt;Methods and results: The ABI was examined in 13,211 participants (aged 21-89 years) in a health evaluation programme. The mean ABI was lower in women than in men at all ages. The ABI was lowest at %26lt;40 years, and increased with age; the maximum was at 60-69 years in both sexes. In participants %26lt;40 years, 186 (22%) of women and 108 (9.8%) of men had a borderline ABI (0.9-1.0). The prevalence of an ABI %26lt;= 0.9 in men increased with age, and sharply rose to 3.3% at %26gt;= 70 years. Conversely, women demonstrated a J-curve relationship, where the prevalence of an ABI %26lt;= 0.9 was lowest at 60-69 years (0.2%), and increased at %26lt;40 (0.9%) and %26gt;= 70 years (1.6%). The prevalence of atherosclerotic risk factors was higher in participants with an ABI %26lt;= 0.9 than those with an ABI %26gt;0.9 in men, both %26lt;= 60 and %26gt;60 years, and in women %26gt;60 years. In women %26lt;= 60 years, however, the prevalence of atherosclerotic risk factors in participants with an ABI %26gt;0.9 was as small as those with an ABI %26lt;= 0.9. %26lt;br%26gt;Conclusion: The ABI increased with age until 60-69 years, and was lower in women than in men. It is unlikely that a low ABI in younger healthy women always indicate that existence of arterial stenosis.

• 出版日期2014-6