Using CRISPR to inactivate endogenous retroviruses in pigs: an important step toward safe xenotransplantation?

作者：Ross Michael J^*; Coates P Toby

来源：Kidney International, 2018, 93(1): 4-6.

DOI：10.1016/j.kint.2017.11.004

• gene expression
• gene therapy
• microbiology

Xenotransplantation could theoretically provide an unlimited supply of organs for patients living with end-stage kidney disease and other end-stage organ failure, but severe rejection and concerns about possible transmission of zoonotic infections remain important obstacles. In a recent study, investigators used CRISPR-cas9 to generate genetically modified pigs in which all endogenous retroviruses were inactivated. This approach may address one important barrier to the feasibility of clinical trials of xenotransplantation.

• 出版日期2018-1