Systemic markers of oxidative status and colorectal adenomatous polyps

作者：Siamakpour Reihani Sharareh; Scarbrough Peter M; Wang Frances; Spasojevic Ivan; Base Karel; Sedjo Rebecca; D'Agostino Ralph B Jr; Il'yasova Dora^*

来源：Annals of Epidemiology, 2012, 22(8): 587-591.

DOI：10.1016/j.annepidem.2012.05.001

• Oxidative stress
• Biomarkers
• F2-Isoprostanes
• Adenomatous polyps
• Adenoma
• Colorectal cancer
• Epidemiology

Purpose: Oxidative damage has been implicated in carcinogenesis. We hypothesized that elevated systemic oxidative status would be associated with later occurrence of colorectal adenomatous polyps, a precursor of colorectal cancer.
Methods: We examined the prospective association between four systemic markers of oxidative status and colorectal adenomatous polyps within a nondiabetic subconort of the Insulin Resistance Atherosclerosis Study (n = 425). Urine samples were collected from 1992 to 1994 and colorectal adenomas prevalence were assessed in 2002 to 2004. Oxidative status markers were assessed, which included four F-2-isoprostanes (F-2-lsoPs) from the classes III and IV: iPF2 alpha-III, 2,3-dinor-iPF2 alpha-III (a metabolite of iPF2 alpha-III), iPF2 alpha-VI. and 8,12-iso-iPF2 alpha-VI. All biomarkers were quantified using liquid chromatography tandem mass spectrometry. Prospective associations were assessed using multivariate logistic regression analysis.
Results: The adjusted odds ratio (OR) (95% confidence interval [CI]) for occurrence of colorectal adenomatous polyps and scaled to 1 SD of F2-IsoP distribution were 1.16(95% CI. 0.88-1.50), 0.88 (95% CI, 0.63 - 1.17), 1.04 (95% CI, 0.80-1.34), and 116(95% CI, 0.90-1.48) for iPF2 alpha-III, iPF2 alpha-VI, 8,12-iso-iPF2 alpha-VI, and 2,3-dinor-iPF2 alpha-III, respectively.
Conclusions: The lack of association between F2-lsoPs and adenDmatous polyps does not support the hypothesis that elevated oxidative status is associated with colorectal adenomatous polyp occurrence during a 10-year period of follow-up.

• 出版日期2012-8