A high normal thyroid-stimulating hormone is associated with arterial stiffness, central systolic blood pressure, and 24-hour systolic blood pressure in males with treatment-naive hypertension and euthyroid

作者：Kwon Beom June; Roh Ji Woong; Lee Su Hyun; Lim Sung Min; Park Chan Seok; Kim Dong Bin; Jang Sung Won; Chang Kiyuk; Kim Hee Yeol; Ihm Sang Hyun^*

来源：International Journal of Cardiology, 2014, 177(3): 949-956.

DOI：10.1016/j.ijcard.2014.09.200

• Arterial stiffness
• Euthyroid
• Hypertension
• Systolic blood pressure
• Thyroi-stimulating hormone

Background: We compared the results of laboratory examinations, echocardiography, arterial stiffness, central blood pressure (BP) and ambulatory BP monitoring (ABPM) between treatment-naive patients with low normal thyroid-stimulating hormone (TSH) and those with high normal TSH levels. %26lt;br%26gt;Methods: A total of 285 consecutively-eligible patients with both treatment-naive hypertension and euthyroid were divided into two groups: those with low-normal TSH (0.40-1.99 mu IU/mL, group 1) and high-normal TSH (2.00-4.50 mu IU/mL, group 2) and compared according to group and gender. %26lt;br%26gt;Results: Males were divided into group 1 (n = 113, 68.9%) and group 2 (n = 51, 31.1%) and females were divided into group 1 (n = 71, 58.7%) and group 2 (n = 50, 41.3%). Multivariate analyses revealed that the augmentation index (71.0 [adjusted mean] +/- 1.7 [standard error] vs. 78.8 +/- 2.5%, P = 0.045), central systolic BP (SBP) (143.3 +/- 2.1 vs. 153.0 +/- 3.2 mm Hg, P = 0.013), systemic vascular resistance (SVR, 21.4 +/- 0.6 vs. 23.9 +/- 0.9 mm Hg/L/min, P = 0.027), SBP during daytime (144.1 +/- 1.4 vs. 151.6 +/- 2.1 mm Hg, P = 0.004) and nighttime (130.4 +/- 1.6 vs. 138.5 +/- 2.5 mm Hg, P = 0.008), and nighttime pulse pressure (PP, 47.2 +/- 0.9 vs. 51.7 +/- 1.4 mm Hg, P = 0.010) were significantly higher while cardiac output (5.4 +/- 0.1 vs. 4.8 +/- 0.2 L/min, P = 0.043) and PP amplification (1.02 +/- 0.02 vs. 0.94 +/- 0.03, P = 0.039) were significantly lower in the male group 2 than in the male group 1. However, there were no significant differences between the two groups in females. %26lt;br%26gt;Conclusions: Treatment-naive hypertensive males with high normal TSH and euthyroid showed higher arterial stiffness, central SBP, SVR, and SBP in ABPM and lower cardiac output and PP amplification as compared to the the low normal TSH group, but not females.

• 出版日期2014-12-20