A Functional MicroRNA-155 Ortholog Encoded by the Oncogenic Marek's Disease Virus

作者：Zhao Yuguang; Yao Yongxiu; Xu Hongtao; Lambeth Luke; Smith Lorraine P; Kgosana Lydia; Wang Xiaowei; Nair Venugopal^*

来源：Journal of Virology, 2009, 83(1): 489-492.

DOI：10.1128/JVI.01166-08

Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncogenic herpesviruses associated with distinct types of lymphomas in different species encode functional miR-155 orthologs suggested the importance of this miRNA in regulatory pathways and the biology of lymphomagenesis.

• 出版日期2009-1-1